CORDIS Project
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This project investigates the RAS-MAPK signaling pathway, focusing on the role of KRAS dimers in cancer. It aims to understand how these complexes influence drug sensitivity and to identify potential therapeutic targets to disrupt oncogenic signaling in cancer patients.
Cellular homeostasis is controlled by the RAS-MAPK pathway.
This pathway is dysregulated in human diseases, especially cancer, in which more than 50% of cases carry aberrations that hyperactivate RAS-MAPK signaling.
In this context, KRAS mutations are the most frequent oncogenic drivers.
Therapeutic suppression of pathogenic KRAS-RAF-MAPK signaling to achieve disease control in cancer patients still represents a challenging target. KRAS dimers and multimers at the membrane (collectively referre…
UNIVERSITA DEGLI STUDI DI TORINO
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