CORDIS Project
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This research focuses on the structural and functional properties of Kainate receptors, which are important for understanding epilepsy and mood disorders. By employing advanced imaging techniques, the project aims to elucidate the assembly and interactions of these receptors at synapses.
Kainate receptors (KARs) are glutamate-gated ion channels (iGluRs) known as neuronal circuit modulators.
Because of their involvement in epilepsy and mood disorders, they represent an important pharmacological target.
Over the past decade, we have learned a lot about synaptic KARs, but their assembly, function and pharmacology remain elusive compared to the closely-related alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR).
During my PhD, I used electrophysiology to study…
UNITED KINGDOM RESEARCH AND INNOVATION
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