CORDIS Project
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This research aims to elucidate the structure and regulation of adhesion sites in cells, focusing on desmosomes and adherens junctions. By employing cryo-electron tomography, the project seeks to visualize these structures and understand their interactions with the cytoskeleton.
Cells sense, affect and respond to their environment through the fundamental function of adhesion.
Several types of adhesion sites, which are mediated via dynamically maintained multi-protein structures, anchor extracellular-matrix proteins to the cytoskeleton.
Despite considerable efforts, the long-standing questions of how adhesion sites are formed, structured and regulated remain unanswered.
In this research plan we will investigate desmosomes and adherens junctions by cryo-electron tomograph…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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