CORDIS Project
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This project investigates the genetic basis of schizophrenia by examining non-coding genetic variants that may affect gene regulation during neurodevelopment. It uses cortical organoids to study the impact of these variants on gene expression and neuronal maturation.
What makes us susceptible to a genetic disease is a central question in human genetics.
Although, coding mutations have revealed the mechanisms of many genetic diseases, the same approach is not adequate to unravel the etiology of complex diseases such as schizophrenia (SCZ).
Genome wide association studies revealed that the majority of SCZ-associated polymorphisms map to the non-coding regions and possibly alter gene expression.
However, the functional consequence of these polymorphisms on gene…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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