CORDIS Project
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This project explores the role of CUL4-RING E3 ligases in cell division, particularly during mitosis. By identifying specific protein substrates and regulators, it aims to uncover new insights into the mechanisms that ensure accurate chromosome alignment and cell division in human cells.
Mitosis relies heavily on ubiquitin-dependent degradation of specific protein substrates, mainly by the APC/C and CUL3-RING E3 ligases (CRL3s).
In contrast, CUL4-RING E3 ligases (CRL4s) have previously been associated with silencing of gene expression, DNA replication and repair.
However, unpublished data from the Peter laboratory suggest that CRL4s may also be important for progression through mitosis.
In this grant proposal, I thus present two complementary approaches to investigate the role o…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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