CORDIS Project
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This project investigates the role of bromodomain-containing proteins in the parasite Trypanosoma cruzi, which causes Chagas Disease. By developing small molecule probes, the aim is to understand these proteins' functions and potentially create new treatment methods for the disease.
Lysine acetylation is a key protein post-translational modification (PTM) found throughout the cellular environment and across the range of species.
This PTM is dynamic, with histone acetyl transferases (HATs) acetylating lysine, and histone deacetlyases (HDACs) reversing the modification.
In addition, proteins modules bromodomains, have been identified that bind to acetylated lysine (KAc) and mediate protein-protein interactions.
In humans, bromodomains exist as part of larger proteins, many of…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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