CORDIS Project
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This project aims to understand how neutralizing antibodies are generated in response to live viruses within lymph nodes. By using advanced imaging techniques, it will investigate the interactions between B cells and viruses to improve vaccine strategies.
Objective.
Our objective is to elucidate how neutralizing antibody (nAb) responses against live viruses are generated in vivo within lymph nodes (LNs).
To this end we will make use of state-of-the-art imaging technology (i.e. multiphoton intravital microscopy [MP-IVM]), fluorescent replication-competent viruses and dedicated mouse models.Background/Rationale. nAbs are critical for virus control, prevention of re-infection and protection conferred by available vaccines.
Thanks to the recent adven…
UNIVERSITA VITA-SALUTE SAN RAFFAELE
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