CORDIS Project
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This project investigates the generation of regulatory T cells from naive T cell precursors to enhance immune tolerance and improve treatments for autoimmune diseases and cancer. It employs molecular profiling techniques to understand the mechanisms behind this process in humans.
Regulatory T cells (Tregs) suppress other immune cells and, thus, are critical mediators of peripheral self-tolerance, preventing autoimmune disease but hampering tumor rejection.
Therapeutic manipulations of Treg number and function are therefore subject to numerous clinical investigations.
First in-man trials of adoptive Treg transfer to prevent graft-versus-host disease showed very promising outcomes.
Yet, the number of naturally occurring Tregs (nTregs) is minute, encouraging the complementa…
KAROLINSKA INSTITUTET
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