CORDIS Project
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This project investigates the role of cancer stem cells in Acute Myeloid Leukaemia and aims to develop targeted therapeutic antibodies. Using innovative screening methods, it seeks to isolate antibodies that specifically recognize leukaemia stem cells to improve treatment outcomes.
One main objective of our ERC Advanced Grant project (InMec, No 341131) was to determine how cancer stem cells (CSCs) contribute to tumour growth, and the relative impact of quiescent versus proliferative CSCs.
In Acute Myeloid Leukaemia (AML), our results strongly suggest that quiescent leukaemia stem cells are critical for leukaemia maintenance and relapse after treatments. AML is an aggressive and frequently fatal hematologic malignancy.
It is usually sensitive to chemotherapy at its onset, l…
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Italy, MILANO
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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