CORDIS Project
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This research investigates the mossy fiber synapse in the hippocampus to determine its role in neuronal firing and information processing. By using advanced imaging techniques, the study aims to clarify how these synapses contribute to learning and memory.
A commonly repeated maxim is that an individual cortical neuron receives synaptic input from tens of thousands of presynaptic partners, with each individual connection carrying only minor weight.
In that case, concerted firing by many presynaptic neurons is required to cause an action potential in the postsynaptic neuron.
However, there is inconclusive evidence that the mossy fiber synapse (the second connection in Cajal’s heavily studied “trisynaptic circuit” of the hippocampus) is powerful eno…
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
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