CORDIS Project
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This project explores the role of Hyperpolarization-activated Cation Non-selective channels in neuronal excitability and synaptic transmission. By studying these channels in the entorhinal cortex of mice, the research aims to understand their influence on neurotransmitter release and neural network function.
Voltage-gated ion channels are important determinants of neuronal excitability.
The Hyperpolarization-activated Cation Non-selective (HCN) channels are voltage-gated ion channels that open with hyperpolarization at subthreshold potentials.
Four subtypes (HCN1-4) have been cloned.
There is considerable interest in HCN1 channels as they have been shown to have roles in physiological processes such as learning and memory as well as pathophysiological conditions such as epilepsy.
Many studies have s…
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