CORDIS Project
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This project aims to revolutionize the study of cardiac arrhythmias by developing patient-specific heart tissue models using human induced pluripotent stem cells and genome-editing technologies. It focuses on atrial fibrillation, utilizing advanced tissue engineering and optogenetics to explore new treatment strategies…
Cardiac arrhythmias are responsible for significant morbidity and mortality.
However, the study and treatment of these rhythm disorders have been hampered by the lack of relevant human cardiac tissue models, specifically those reflecting patient/disease-specific abnormalities, by paucity of methods for long-term electrophysiological analysis of the tissue, and by the inability to perform targeted, high-resolution, reversible, and functional perturbations of the system.
To address these challenge…
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