CORDIS Project
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This project investigates the role of specific immune cells in the progression of idiopathic pulmonary fibrosis. It aims to explore potential therapeutic strategies by targeting a protein that influences these cells' activation.
The problem:
Idiopathic pulmonary fibrosis (IPF) is a rare, progressive lung disease resulting in respiratory failure. IPF is irreversible and patient’s median survival is 3-5 years post-diagnosis.
The only curative recourse is lung transplantation because nintedanib and pirfenidone, the only two treatment options slow disease progress but do not cure or cause disease regression.
Specific depletion of profibrotic monocyte-derived macrophages (MDMs) protects mice against pulmonary fibrosis sugges…
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
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