CORDIS Project
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This project focuses on studying border-associated macrophages in the brain by using a chimeric mouse model. It aims to understand the development and function of these immune cells through genetic analysis and advanced techniques, bridging existing knowledge with innovative methodologies.
Border-associated macrophages (BAMs) are macrophages that reside in specific anatomical interfaces between the brain and the blood circulation.
Due to limited access to fresh human tissues from those anatomical sites, our understanding of human BAM development and function remains poor.
It was previously observed that human hematopoietic stem cells from umbilical cord blood take up residence and differentiate into BAM-like macrophages when injected into the brains of neonatal mice expressing hum…
VRIJE UNIVERSITEIT BRUSSEL
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