CORDIS Project
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This project investigates how transcriptional regulation occurs in Bacillus subtilis by using advanced imaging techniques to observe two key repressors, CggR and CcpN, in live cells. The goal is to understand their roles in the carbon metabolic cycle and how they influence enzyme production in gram-positive bacteria.
This application proposes the study of transcriptional regulation in Bacillus subtilis by direct, in vivo, observation using state-of-the-art two-photon fluorescence correlation spectroscopy.
The project involves the study of two transcriptional repressors from B. subtilis, CggR and CcpN.
Much work has been done in vitro on CggR and CcpN (Zorrilla et al, 2007a;
Zorrilla et al, 2007b;
Zorrilla et al, 2008a;
Zorrilla et al, 2008b) since their discovery in the sequencing of the B. subtilis genome(K…
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