CORDIS Project
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This project focuses on developing innovative methods to create gene-targeted T cells for cancer therapy. By optimizing viral delivery systems and gene editing technologies, it aims to translate findings into clinical applications for treating hematological cancers and solid tumors.
T cells expressing chimeric antigen receptors (CAR) have transformed cell therapies against some hematological cancers.
As a postdoc, I evolved a synthetic adeno-associated virus (AAV) with tropism against murine T cells, providing a unique tool to study gene targeted T cells in immunocompetent cancer models.
In this proposal, capitalizing on my break-through, I will develop novel strategies to generate gene targeted CAR-T cells in vivo, optimizing AAV delivery in immunocompetent mouse models an…
KAROLINSKA INSTITUTET
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