CORDIS Project
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This project investigates the role of the enzyme interleukin-4-induced 1 (IL4i1) in immune suppression in chronic lymphocytic leukemia (CLL). It aims to understand how IL4i1 affects dendritic cell functions and to explore the potential of IL4i1 deficient dendritic cells in enhancing CLL vaccination strategies.
Chronic lymphocytic leukemia is a common leukemia in adults characterized by an extremely immune suppressive microenvironment, which leads to the failure of otherwise effective immunotherapy regimens including dendritic cell (DC) based tumor vaccines.
Recent attempts to understand immune suppression in CLL provided substantial evidence and identified that over-expression of amino acid catabolizing enzyme interleukin-4-induced 1 (IL4i1) in CLL and immune cells as key phenomenon in CLL mediated im…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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