CORDIS Project
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This project investigates how Toll-like receptors (TLRs) regulate immune responses to pathogens, focusing on the role of Bcl-3 in mediating tolerance to inflammatory signals without affecting antimicrobial defenses. It aims to uncover the molecular mechanisms behind selective gene regulation in immune responses.
Toll-like receptors (TLRs) are key microbial sensors essential for the development of innate immunity to pathogens[1]. TLR activation induces the expression of inflammatory cytokines, antimicrobial proteins, and regeneration factors.
Uncontrolled activation of TLRs leads to the development of fatal inflammatory diseases. TLR activation is tightly controlled to ensure that repeated activation does not lead to sustained activation of target genes - a phenomenon termed TLR-tolerance.
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UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
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