CORDIS Project
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This research project explores the role of von Willebrand factor in the formation of neutrophil extracellular traps, which are linked to thrombosis. It aims to understand the mechanisms behind this process and its implications for various diseases characterized by inflammation and thrombosis.
Thrombosis is a complex process involving activation of endothelial cells, and their release of Weibel-Palade body contents such as von Willebrand factor (VWF) and P-selectin.
This in turn recruits platelets which form aggregates, and leukocytes such as neutrophils.
The recent discovery of neutrophil extracellular traps (NETs) described a novel antimicrobial function of neutrophils. NETs are extracellular chromatin strands containing microbicidal proteins.
The release of histones, serine protea…
KATHOLIEKE UNIVERSITEIT LEUVEN
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