CORDIS Project
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This project investigates how certain proteins from Enteropathogenic Escherichia coli and Enterohaemorrhagic Escherichia coli affect cell survival during infection. It focuses on the anti-apoptotic properties of specific bacterial effectors and their interactions with host cell proteins, aiming to understand their role…
Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic Escherichia coli (EHEC) are closely related diarrheagenic pathogens that are important causes of morbidity and mortality worldwide, especially in young children. EPEC and EHEC are known as attaching and effacing pathogens because they intimately adhere to gut enterocytes and instigate effacement of brush border microvilli.
Injection of bacterial effector proteins via a type III secretion system (T3SS) is an integral part of the EPEC…
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