CORDIS Project
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This project aims to explore the genetic changes in pancreatic cancer using genetically modified mice. By analyzing tumor heterogeneity through advanced sequencing, it seeks to identify key genes and pathways involved in cancer progression and treatment resistance.
Cancer is caused by somatically acquired changes in the DNA.
Some of these changes fall in “cancer genes”, conferring clonal selective advantage to the cells that carry the mutant alleles.
Identifying these genes/pathways is of vital importance for a correct understanding of cancer biology as well as for the diagnosis and treatment of human malignancies.
In this respect, the use of genetically modified mice has been extremely useful in the past for characterizing the molecular pathways involved…
UNIVERSIDAD DE CANTABRIA
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