CORDIS Project
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This project explores sex differences in intestinal cell types, focusing on enterocytes and neurons. By studying these differences in fruit flies and organoids, it aims to understand their impact on physiology and disease susceptibility, potentially leading to new interventions.
Sex differences in intestinal plasticityMales and females often differ in their physiology and disease susceptibility.
Sex hormones play key roles in sculpting and maintaining such sex differences, but increasing evidence points to a contribution of cell-intrinsic mechanisms.
We are only beginning to understand the molecular mediators of these intrinsic mechanisms, and little is known about the organs where they function and their effects at the whole-organism level.
Our work in flies recently r…
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