CORDIS Project
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This project explores how protein aggregation affects cell fitness using yeast models. By manipulating protein expression and tracking aggregation, it aims to uncover evolutionary principles that govern protein behavior in cells, contributing to our understanding of diseases like Alzheimer's and Parkinson's.
Protein misfolding and aggregation are associated with an increasing number of human disorders, such as Alzheimer’s disease and Parkinson’s disease.
Additionally, the formation of insoluble deposits during recombinant protein production impedes the commercialization of several peptide drugs.
Recent computational studies highlight the existence of a selective pressure to escape from protein aggregation; exerted both on protein sequence and gene expression levels.
However, direct experimental evid…
MEDICAL RESEARCH COUNCIL
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