CORDIS Project
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This project focuses on understanding the genetic basis of complex traits by studying the yeast Saccharomyces cerevisiae. It aims to explore how genetic variations influence protein functions and metabolite levels, ultimately linking these to overall fitness.
Many important traits are heritable, and have a strong genetic component.
Numerous genome-wide association studies of common human diseases have corroborated that no single gene explains all or even a large part of their heritable variability.
Each effect of a single locus genotype on such a global trait has to be mediated by cellular, tissue, and organ phenotypes.
Thus, genetics of intermediate cellular traits is central to developing an understanding of the genetic basis of complex traits.
Stu…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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