CORDIS Project
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This project investigates how post-translational modifications, specifically ubiquitination, regulate stem cell maintenance and differentiation in the small intestine. Using intestinal organoids, the research aims to identify key mechanisms that ensure proper stem cell homeostasis, which is crucial for tissue health.
The epithelium of small intestine has a higher self-renewal rate than any other mammalian tissues.
This is fuelled by the intestinal stem cells which reside near the bottom of crypt.
Tight regulation of the adult stem cell number is required to sustain an adequately sized population for optimal tissue homeostasis.
Mis-regulation of homeostasis results in either hyperplasia or loss of stem cells.
Although transcriptional regulation of stem cell homeostasis regarding multipotency and differentiati…
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