CORDIS Project
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This project investigates the role of intestinal stem cells in the progression of colorectal cancer. It focuses on understanding how these cells contribute to tumor recurrence and metastasis, using a novel mouse model to track cancer development.
Constitutive activation of the Wnt pathway is the key step for initiation of colorectal cancer (CRC).
Wnt signaling also plays an essential role in the maintenance of intestinal stem cells (ISCs).
In addition, acquisition of a constitutive crypt stem/progenitor phenotype represents the first step towards malignancy.
The identification of the Wnt target gene Lgr5 as a marker for ISCs and the finding that Lgr5+ ISCs represent the origin of intestinal cancer suggest that specific features of ISC ar…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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