CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project focuses on the metabotropic glutamate receptor 5, a key player in brain function and drug development. It aims to explore the mechanisms of receptor internalization and create tools for studying G protein-coupled receptor signaling.
The metabotropic glutamate receptor 5 (mGlu5) is part of the large family of G protein-coupled receptors (GPCRs) that are the target of 30-40% of marketed drugs. mGlu5 is a key regulator of synaptic plasticity in the brain and a major drug target for a wide range of diseases, such as Fragile X syndrome.
Agonist-induced internalization is a major regulatory mechanism for GPCR signalling.
Interestingly, mGlu5 internalizes via a mechanism that is distinct from the canonical beta-arrestin mediated p…
KOBENHAVNS UNIVERSITET
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
