CORDIS Project
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This project investigates the mechanisms behind inflammatory bowel diseases (IBD) and their resistance to therapy. It focuses on the role of epithelial cell mechanics and immune responses in IBD progression, aiming to identify new therapeutic targets for better treatment outcomes.
Inflammatory bowel diseases (IBD) are a heterogeneous group of disorders characterized by gastrointestinal tract inflammation, being Crohn's Disease and Ulcerative Colitis, the most clinically abundant. IBD affects around 6.8 million people all over the world, being Europe the continent with the highest prevalence.
Although anti-TNF-α monoclonal antibodies are a breakthrough therapy, almost 40% of IBD patients do not respond to therapy or acquire resistance.
This leads to uncontrolled inflammati…
UNIVERSITATSKLINIKUM ERLANGEN
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