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INTERCELLMED investigates the role of potassium, protons, and oxygen in tumor cells using advanced 3D culture techniques. The project focuses on developing sensing technologies to monitor cellular interactions and responses to treatments in a controlled environment.
This project aims to investigate the role of potassium (K+), protons (H+) and oxygen (O2) gradients in the extracellular space of tumour cells grown in 3D cultures by using a combination of imaging, cell biology and in silico analyses.
By embedding ratiometric fluorescent particle-based sensors within 3D scaffolds, the changes in target analyte concentrations can be monitored and used to study the interactions between tumour cells and stromal cells in 3D tumoroids/scaffolds and to monitor respon…
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