CORDIS Project
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This project investigates the role of the protein L-isoaspartyl methyltransferase (PIMT) in protein repair and its connection to aging. By studying the effects of PIMT deficiency in mice and its interaction with insulin-like signaling, the project aims to uncover mechanisms that influence lifespan and protein function.
The protein L-isoaspartyl methyltransferase (PIMT) is well known for its protein repair function, namely the reconversion of deamidated and/or isomerized asparaginyl and aspartyl residues (L-isoaspartyl residues) into their normal, non-isomerized forms.
The conversion of biomolecules to non-useful and potentially toxic products by unwanted chemical reactions represents probably an important aspect of the aging process in living organisms.
To the extent that they can minimize the accumulation of…
UNIVERSITE DU LUXEMBOURG
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Belgium, Bruxelles / Brussel
Type: Research institute
Activity type: Research Organisations
SME: No
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