CORDIS Project
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This project investigates the Integrator complex's role in RNA polymerase II's transcriptional regulation and processing of small nuclear RNAs. It aims to characterize the interactions and functions of the Integrator complex, which is crucial for gene expression and cellular growth control.
The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is essential for transcriptional regulation and RNA processing of protein coding genes. A large body of data also implicates the CTD in the transcription and processing of RNAPII-dependant spliceosomal U small nuclear RNAs (U1 to U5 snRNAs).
Recently, we discovered a RNA polymerase II complex that contains at least twelve novel subunits, termed the Integrator complex, in addition to core RNAPII subunits.
Two of these subunits display sim…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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