CORDIS Project
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This research proposes a new hypothesis for understanding schizophrenia by linking positive symptoms with cognitive deficits. It aims to investigate the underlying mechanisms in a mouse model, focusing on the relationship between cortical activity and dopamine regulation to improve treatment strategies.
An integrated hypothesis for cognitive and positive symptoms in schizophrenia:Schizophrenia is a complex developmental brain disorder with three main clusters of symptoms: (i) positive (psychosis, delusions and hallucinations), (ii) negative (reduced motivation and social withdrawal), and (iii) cognitive (memory and executive function deficits).
For the last 50 years, the only effective treatment has consisted of antipsychotics targeting dopamine receptors.
Yet, antipsychotics control mostly the…
UNIVERSITETET I OSLO
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