CORDIS Project
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The INTEGRATE project investigates mitochondrial quality control processes, focusing on how protein aggregates trigger responses that affect cellular functions. By utilizing advanced imaging and biochemical techniques, the project aims to clarify the mechanisms of mitochondrial health and their implications for disease…
Quality control processes maintain mitochondrial health, enabling cellular functions such as bioenergetics, metabolism, Ca2+ signaling, and cell death regulation.
Mitochondrial proteases, unfolded protein response, asymmetric fission, vesicle shedding, and mitophagy all contribute to organelle quality.
However, the specific triggers for these processes remain unclear.
While unfolded protein accumulation appears to be a common trigger, the mechanism by which it initiates diverse responses remains…
UNIVERSITA DEGLI STUDI DI PADOVA
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