CORDIS Project
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INTEGRATA focuses on developing inhibitors targeting NAD biosynthesis and signaling in cancer. The project aims to train researchers while assessing the pharmacology and toxicity of new therapeutic agents in preclinical models.
Deregulated nicotinamide adenine dinucleotide (NAD) biosynthesis and signaling underlies many aspects of carcinogenesis. NAD biosynthetic enzymes, such as nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyltransferase (NAPRT), are commonly upregulated in cancer cells, where they fuel increased metabolic demands and downstream enzymes involved in DNA repair and in the promotion of cell growth, cell motility, de-differentiation and immune escape.
In addition, NAD-produ…
UNIVERSITA DEGLI STUDI DI GENOVA
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Germany, Bonn
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
United Kingdom, Sheffield
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Switzerland, Lausanne
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SME: No
Switzerland, Geneve
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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