CORDIS Project
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This project investigates how nutrient levels affect pancreatic β cell functions beyond insulin secretion, focusing on processes like autophagy and granule turnover. It aims to understand the mechanisms leading to β cell failure in type 2 diabetes, which is critical for developing new treatment strategies.
The pancreatic β cell harbors an exemplary nutrient sensing machinery that is coupled to secretion of insulin.
While mechanisms governing regulation of insulin secretion in response to nutrients were widely investigated, little is known about how nutrients impact on other basic cellular processes such as insulin granule turnover, autophagy and cellular growth, deregulation of all of which have been demonstrated to be involved in β cell failure in type 2 diabetes (T2D). T2D represents a major hea…
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
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