CORDIS Project
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This research explores the insulin/IGF-1 signaling pathway's role in aging using the model organism C. elegans. It focuses on understanding how the ire-1 gene influences longevity and insulin regulation under conditions of reduced signaling.
The insulin/IGF-1 signaling pathway is a major conserved metabolic pathway that regulates aging and lifespan in worms, flies, and mammals.
Using C.elegans as a model system, I discovered that ire-1, a highly conserved ER stress response gene, makes a big contribution to the longevity of animals with reduced insulin/IGF-1 signaling. I further discovered that inactivation of ire-1 results in a striking accumulation of DAF-28, an insulin-like peptide, in the body cavity of animals with reduced insu…
BAR ILAN UNIVERSITY
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