CORDIS Project
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This project investigates the early molecular events leading to rheumatoid arthritis in individuals with specific autoantibodies. By utilizing advanced sequencing and imaging techniques, it aims to understand the transition from autoimmunity to inflammation, ultimately guiding the development of preventive therapies.
Rheumatoid Arthritis (RA) is a prototypic T cell- and B cell-driven inflammatory autoimmune disease that affects around 1% of the population worldwide and creates a severe burden for patients as well as substantial socioeconomic costs for society.
Hallmarks of RA are a destructive inflammation of peripheral joints as well as the presence of autoantibodies such as anti-citrullinated protein antibodies (ACPA).
Although ACPA are considered to represent major drivers of RA pathology, they can be als…
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