CORDIS Project
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This project develops a technique called super-resolution cryo-correlative light and electron microscopy (SRcryoCLEM) to locate specific proteins within whole mammalian cells. By combining advanced imaging methods, it aims to enhance our understanding of antibody functions in human immunity, facilitating the design of…
Structural biology provides insights into protein function but generally requires purified complexes, which necessitates removing the protein from its native context.
We therefore lose in situ information.
Cryo-electron tomography (cryoET) provides this information, but finding a specific protein in a cell is akin to searching for a needle in a haystack 50 m tall.
We are at the forefront of developing a technique to solve this problem; by combining super-resolution (SR) light microscopy on sampl…
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