CORDIS Project
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InProSpecT focuses on developing advanced chemical probes for studying protein structures and dynamics. By creating custom-tailored labeling strategies, it aims to enhance the understanding of protein interactions and behaviors in real-time.
Protein structures, including their complexes, determine their specific function and the molecular working mechanisms.
The astonishing developments in X-ray crystallography and cryo-EM allow insights into atomic levels of protein structures, however, commonly on their static, solid state conformations.
Nuclear magnetic resonance (NMR) and single molecule fluorescence spectroscopy, on the other hand, allow observations of protein dynamics in solution, in real-time.
In particular, specific interme…
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