CORDIS Project
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This project investigates how the human INO80 complex remodels chromatin to facilitate the repair of double-stranded DNA breaks, which can lead to genomic instability and cancer. By using advanced imaging techniques, the project aims to uncover the mechanisms of nucleosome dynamics during DNA repair processes.
The proposal aims at the study of the molecular mechanisms involved in the starting steps of the repair of the most severe type of DNA lesions, the double-stranded DNA breaks (DSBs). DSBs are caused by either environmental stress or by endogenous DNA metabolic processes.
Inaccurate repair of DSBs leads to genomic instability, and thus, to cell death or cancerous malformations.
Enzymes acting in DNA repair processes are required to access to DNA.
This is, however, hampered by the compact and stab…
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