CORDIS Project
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This project aims to develop a novel double-barrel nanopipette for monitoring and regulating neuropeptides within individual vesicles in the context of neurodegenerative diseases. The tool will enable in situ quantification and targeted delivery of therapeutic agents, enhancing our understanding of disease mechanisms.
Neurodegenerative diseases (NDDs) represent a growing global crisis with profound social and economic implications.
As essential signaling molecules, neuropeptides (NPs) packaged within dense-core vesicles (DCVs) play a critical role in modulating neural communication and have been strongly implicated in NDD pathogenesis.
The ability to in situ monitor and regulate NPs within individual vesicles is critical for unraveling disease mechanisms and developing early diagnostic and therapeutic strateg…
UGOT - GOETEBORGS UNIVERSITET/UNIVERSITY OF GOTHENBURG
GOETEBORGS UNIVERSITET
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