CORDIS Project
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This project aims to develop a molecular model to predict the behavior of disordered proteins in neurodegenerative diseases. It focuses on understanding how mutations and modifications affect protein condensation and identifying small molecules that can enhance protein dynamics, potentially leading to new therapeutic s…
With population ageing and the lack of effective treatments, neurodegenerative diseases (NDs) are expected to pose an increasingly severe challenge to healthcare systems worldwide. A hallmark of NDs is the presence of insoluble aggregates of intrinsically disordered proteins (IDPs) and proteins with disordered regions in neuronal cells.
Growing evidence suggests that these disease-associated proteins condense into liquid-like droplets through liquid-liquid phase separation (LLPS).
Dysregulation…
KOBENHAVNS UNIVERSITET
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