CORDIS Project
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This project investigates the role of reactive oxygen species in cell fate decisions at the G1 checkpoint using a novel fluorescent biosensor. It focuses on the redox state of various cell types under different growth conditions to understand how these factors influence cell growth, differentiation, and senescence.
Reactive oxygen species are derivatives of aerobic metabolism.
Their production is finely regulated to protect cells against severe and permanent damage to cellular components that could ultimately lead to programmed cell death.
However at low levels, ROS act as second messagers in several signalling pathways leading to growth, differentiation, senescence or cell death.
This dual function of ROS appears to be due to differences in their concentrations, their sub-cellular localization and the pul…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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