CORDIS Project
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This project investigates how low oxygen levels in tumors affect the behavior of tumor-infiltrating lymphocytes. It aims to understand the molecular mechanisms involved and their implications for improving immunotherapy strategies against cancer.
The tumor microenvironment determines many of the hallmarks of cancer.
Stromal components and malignant cells dialogue and mutually change their functional responses.
Tumor infiltrating lymphocytes (TILs) are a prominent feature of solid tumors, whose presence has correlation with a better survival in cancer-patients.
However TILs are severely restrained in their ability to tackle tumors as a result of immunosuppressive mechanisms.
This proposal is based on the hypothesis that low levels of oxyg…
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