CORDIS Project
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This project investigates the role of myofibroblasts in spondyloarthritis, focusing on how these cells produce inflammatory cytokines that drive tissue inflammation. By exploring the molecular mechanisms involved, it aims to identify new therapeutic targets for treating chronic inflammatory diseases.
Pro-inflammatory cytokines play a crucial role in chronic inflammatory diseases.
Focusing on spondyloarthritis (SpA), a prevalent and debilitating rheumatic condition characterized by inflammation and abnormal new bone formation, we demonstrated that TNF and IL-23/IL-17 inhibition potently blocks inflammation.
However, these treatments have no proven effect on pathologic new bone formation and the resulting structural damage, indicating the unmet need for understanding upstream disease mechanism…
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
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