CORDIS Project
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This project investigates the structural mechanisms of non-canonical inflammasomes, which play a crucial role in the immune response by detecting bacterial components. By employing advanced imaging techniques, the research aims to clarify how these complexes assemble and activate, providing insights for inflammation-re…
Inflammasomes are essential components of the innate immune system that form cytosolic multi-protein complexes restricting pathogen growth and coordinating inflammatory signalling.
Among these, non-canonical inflammasomes are unique lipid-protein assemblies where inflammatory caspases directly sense and oligomerise on bacterial lipopolysaccharide (LPS), triggering a response that ultimately induces lytic cell death.
Despite the critical role of non-canonical inflammasomes, the transient and hete…
TECHNISCHE UNIVERSITEIT DELFT
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