CORDIS Project
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This research investigates the role of caspase-11 in the activation of inflammasomes, which are crucial for the immune response against infections. Using knockout mice, the project aims to clarify how caspase-11 influences innate immunity and may lead to new treatments for autoimmune diseases.
Innate immune cells such as macrophages and dendritic cells produce potent inflammatory cytokines to mount an appropriate immune response against microbial threats.
The related cytokines interleukin (IL)-1beta and IL-18 require cleavage by the cysteine protease caspase-1 to generate biologically active IL-1beta and IL-18.
Caspase-1 itself is synthesized as zymogen that interacts with certain members of the intracellular NOD-like receptor (NLR) family in infected macrophages to form large protein…
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