CORDIS Project
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This project investigates pyroptosis, a type of programmed cell death linked to the immune response. It focuses on understanding the role of gasdermin proteins in this process, which could lead to new treatments for infections and inflammatory diseases.
Pyroptosis is a lytic pro-inflammatory type of programmed cell death that is induced by inflammatory caspases, a family of proteases that control the innate immune response to infection, injury or noxious substances.
Inflammatory caspases are activated within so-called inflammasomes, cytosolic signalling platforms that are assembled by pattern recognition receptors upon the detection of pathogen- or host-derived danger signals.
Pyroptosis is essential for antimicrobial host defense, but also pro…
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