CORDIS Project
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The project aims to develop a non-invasive screening platform using zebrafish to study inflammation and immune responses. It will enable high-throughput analysis of compounds affecting leukocyte behavior and identify potential new drugs for modulating immune responses.
Despite its fundamental importance, our understanding of the immediate mechanisms directing tissue response and the complex cell-cell communications regulating its resolution remain fairly limited.
Moreover, current anti-inflammatory drugs work relatively unspecific as on-off switches, thereby exhibiting considerable side effects.
Studies on innate immunity have benefitted from the introduction of the transparent zebrafish larvae as an assay system.
Transgenic fish expressing fluorescent protein…
KARLSRUHER INSTITUT FUER TECHNOLOGIE
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