CORDIS Project
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This project investigates the inflammasome, an immune signaling pathway, to understand its activation during infections, particularly with Francisella tularensis. It aims to clarify the interactions between inflammasome components and other immune pathways.
The inflammasome is an innate immune signalling pathway that is key to fight infections.
Inflammasome activation leads to caspase-1 activation, secretion of pro-inflammatory cytokines and host cell death.
Inflammation and cell death can be deleterious for the host and the inflammasome has been involved in numerous inflammatory syndromes.
Despite its key importance in the immune responses to infections and in diseases, the cell biology of inflammasome activation remains unclear.
Particularly, the…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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